Desktop Genetics

Looking for a simple, robust and fast way of analysing your gRNA efficiency?
TIDE generates reliable quantifiable results in seconds with high precision and sensitivity. It is the industry-leading indel analysis tool for NHEJ-mediated genome editing, trusted by thousands of labs around the world and cited in over 340 peer-reviewed publications.
This free webinar will cover:... - Introduction to TIDE - Provide a step-by-step guide from upload to data - How to interpret your results - Troubleshooting the common issues encountered
Sign up today to secure your spot! (limited seats available)
See more

On October the 31st Desktop Genetics will be hosting the "A Guide to TIDE: Tracking of Indels by DEcomposition" webinar, in which our CEO Victor Dillard and CSO Leigh Brody will go step-by-step through a successful CRISPR analysis on TIDE and give tips on how to improve your results! Sign up now> http://ow.ly/SXgV30mppRs

We at Desktop Genetics have been incredibly thankful for the work Callum has put into the company over the past few months. He supported our team to the fullest and fit perfectly into our office. We wish him the best of luck in his future career!
https://www.deskgen.com/…/reflection-of -a-data-science-inte…

Applying CRISPR for human therapy is a very new and remains to be an exciting idea, and we are still learning about all the possibilities it could bring to us. This includes lessons learned about what doesn’t work and where potential hazards are.
Here we review the latest publications shedding light on CRISPR hurdles.
http://ow.ly/WQX930leJ91

Our guest blogger Ines Pinheiro discusses the possibilities of applying CRISPR to treat Neurodegenerative diseases.
What if CRISPR could hep to turn around the clock and prevent diseases such as Alzheimer Dementia to take effect in the first place? http://ow.ly/Vgbu30leIZ2

Our guest blogger, Sara Henriques, describes on our blog how CRISPR could change stem cell-derived organoid research. CRISPR correction and transplantation of patient-derived organoids will one day be possible, and she explains how --> http://ow.ly/bzzD30leIRH

We are proud to announce the addition of the latest web tool developed by the van Steensel lab at the Netherlands Cancer Institute to DESKGEN Cloud. TIDER is the counterpart to the already very successful TIDE platform, and was created specifically for rapidly quantifying homology-directed repair (“HDR”) gene edits. You can now access it as CRISPR tool on the Desktop Genetics website.
https://tider.deskgen.com/

Could the groundbreaking advancements in genome engineering, CRISPR, be the perfect partner to bring stem cell therapies to the next generation? Our Guest Blogger Hendrik de Buhr explores this question in this weeks blog post: Stem Cells and CRISPR - The Way Into the Future?
Read it here: https://lnkd.in/dK7_4md

Thank you to Pint of Science for the chance to share our passion of AI and CRISPR last night! We talked about the way CRISPR and AI will change the world as we know it, from drug discovery to biodesign and the truly distorted way Hollywood gets it wrong.
Our Director of Genomic Services Dr Leigh Brody thoroughly enjoyed the spotlight and we will be looking forward to next years instalment!

Accurate detection of CRISPR activity and specificity is key to establishing a causal relationship between genotypic mutations and phenotypic outcomes. This step, referred to as CRISPR genotyping, applies across genome editing applications.
At Desktop Genetics, we combine targeted amplicon sequencing and internal bioinformatics expertise for accurate validation of on- and off-target genome editing outcomes.
https://www.deskgen.com/…/accurate-dete ction-of-crispr-acti…

We recently completed a collaboration with Professor Waseem Qasim on creating "off-the shelf" CAR T cell therapies to treat leukemia.
Today we share the results with you all on our blog: http://ow.ly/WGTw30k0upR

Join our Director of Genomic Services Dr. Leigh Brody next month on Wednesday the 16th at Pint of Science! She will hold a talk at The Stag in London on the intersection between CRISPR and AI.
She will discuss the effect AI has had on CRISPR to this day and where gene editing will go from here, both clinically and in research. Get your tickets for the Pint of Science event below!

Bill Gates wrote an opinion piece on what he believes to be the ultimate benefits of CRISPR technology, from treating malaria and other diseases to improving agricultural efficiency.
We would be interested in what you thought of his vision for the application of this technology.
Do you find his article a good review on the benefits of CRISPR?
... ow.ly/gCSq30jqPD8
See more

In today’s blog we selected four publications in oncology which caught our eye due to their improvement in specificity and efficiency of patient treatment. The focus for these papers reach from CAR T-cell resistance improvement to genome-wide CRISPR screens identifying druggable vulnerability, highlighting how TIDE was central to quantitatively assess their genome edits.
If you have any publications we should know about do not hesitate to contact us!
http://ow.ly/U9zN30j6anS

We are delighted to announce our first guest blog by Hendrik de Buhr in which he asks- CRISPR Approaching the Clinic: When Will This Be a Reality?
ow.ly/kj3E30iXBql
He addresses the latest developments in clinical trials and patient oriented CRISPR treatments for 2018.
... Hendrik de Buhr is a Marie Curie PhD fellow UMC Utrecht , where he is employing CRISPR knockout-screens to study virology. He gained further lab experience at the Wistar Institute in Philadelphia, where he worked on CRISPR knockins in iPS cells to study melanomagenesis and at the ETH Zurich working on adaptive resistance in cancer.
See more

At Desktop Genetics women make up 50% of the company and 100% of the smiles! With both Dr Leigh Brody and Natalia Vasileia Kokla filling director and managing positions respectively our intern Aide Gomez Miguelez has fantastic role models to look up to.
Happy International Women's Day!

It's the end of the week and the sun is shining: the perfect opportunity to take a quick look back at the changes in CRISPR and genomics in the last few days. What was your research highlight of the week? Which publication really impressed you? Or did you have a personal breakthrough?
We particularly enjoyed reading the research done at Max-Delbrück-Centrum für Molekulare Medizin in which they used CRISPR–Cas9 to turn DNA into a sensitive recording device that documents events within cells — and even erase and re-record information in the same genome (link bellow)

Today on our blog we are talking about the Oligofest hosted by Twist Bioscience and why we believe that such networks event are great for companies and organisations in CRISPR.
But we are always open to new and different experiences so today we are throwing you the question: Which conferences do you find yourself always going back to? Which ones would you recommend and for what reasons?
We are looking forward to your answers!

Have you used our free DESKGEN Cloud CRISPR tools lately? Eager to share your experience? We are all ears and would love to hear your opinion!
We provide a secure cloud-based management and design system for elementary CRISPR genome editing experiments, including knockout and knockin. Also available is software for finding guides anywhere in the genome - includes non-coding regions, and our Guide Picker which compares hundreds of guides within a gene region.